JOBST TECHNOLOGIES GmbH (JT, www.jobst-technologies.com) is a privately owned firm that became part of the swiss sensor manufacturer IST AG (www.ist-ag.com) in 2015. Originally founded in 2002 at the Institute of Microsystems Technology IMTEK (University Freiburg), the company moved to Freiburg’s Biotech Park & Innovation center in 2007 where it has set up numerous R&D and production processes clustering around polymer layer technologies and polymer synthesis and processing. Amongst them are also processes for polymers used in biosensing and other functional membranes like filters. Strategic company development is inspired by the slogan: “Rational technology integration aiming at bio- micro convergence”. The company’s major activity segments are OEM manufacture of multi-biosensing nanofluidic devices (First glucose/lactate sensor for ICU/OT central blood monitoring approved and on market) and rapid prototyped BioMEMS, in vivo biosensors such as CGM’s, sensors for clinical analysers (biosensing technology used in clinical and biotech analyzers), sensing and control microsystems for biotechnology monitoring, enabling microfluidics technologies for bioanalytical microsystems and nanofluidic biosensor-arrays. Just emerging products encompass true-life operational micropumps, also integrated within JT micro-analyzers.
In contrast to any other institution or company doing in vivo application of biosensors, JT has been running since 1994 not only glucose sensors but always additionally lactate sensors in parallel in most of the applications under elaboration. This has not only furbished JT lactate sensors with real word applicability but also generated deep know why in their in-vivo and “at-vivo” use. Additionally, JT’s rich technology portfolio in nanofluidics intimately integrated with biosensors is enabling for numerous non-invasive application approaches. A sensor design that immediately allows the manufacture of a “CLM” (continuous lactate monitor) for subcutaneous application is available. The continuous sensors for Pyruvate, Glutamine, and Creatinine are unique in the market. A Glutamate sensor enables to perform assays for enzymatic activities in a Lab-on-chip format. Micro-pumps developed in a FP7 project are the smallest currently available devices with vacuum generation capability.
Role of JT in the project: Biosensors (Lactate, Glucose, Creatinine and Glutamate) tailoring and integration with micro-needle arrays for ultra-low internal volume micro-fluidics for minimally invasive yet fast responding monitoring. Integration of ion sensors to biosensor array. Implementation of an enzyme assay for the quasi-continuous assay of ALT utilizing static reagent mixing and glutamate biosensor readout. Contribution to subcutaneous metabolite dynamics. Integration, manufacturing, testing, and exploitation aspects.