Public deliverables

WP1 Coordination and management

The aim of this deliverable is to describe the early project management activities which enabled successful project kickoff in May of 2020. Furthermore, it documents the initial project communication activities mostly related to informing the public about the project starting and roles different organisations will have in it. 

Due to the travel limitations induced by COVID-19 pandemic the kick-off meeting was held in a virtual environment through a teleconference. Its organization and approval by the EC were predated by extensive work on risk assessment by each consortium member and as a group, as well as creation of a robust risk mitigation plan for the initial stages of the project. Once the project started the news was spread on the consortium member’s websites, social networks and in the local media. 

Despite the challenges imposed by the pandemic the project has successfully started in May 2020 as originally intended. The consortium overcame the initial obstacles through collaboration and dedication to the common vision. The kick-off meeting was held and communicated to the public. 

On this link you can find all the press releases, articles and media content related to consortium members and the project up to now.

WP2 Co-development, safety, and experimental deployment

WP3 Non-invasive biosensors

Due date: 31.10.2021.
Actual submission date: 31.01.2021.
Partner responsible: TECSR
Reviewed by: TEC

This deliverable aims to report the first prototypes of sensing electrodes with integrated Organic Electrochemical Transistors (OECTs) and Interdigitated Microelectrodes (IMEs). It describes the key aspects of OECTs development: materials, geometries and functionalization of the channel.

                                                                                                Scheme of typical structure of an OECT.

This document shows the information in ALPHA stage for the development of prototypes of sensing electrodes with integrated OECT amplifiers and IME sensors. It will provide the technological capacity for the initial requirements of biomarkers detection such as cortisol and Na+ cations. 

                                                                     Prototypes of sensing electrodes with integrated OECT amplifiers developed by TECSR.

The alpha prototype OECTs and IMEs has been produced and delivered to the partners responsible for functionalization. 

WP4 Minimally invasive biosensors

WP5 Sensor data fusion

Due date: 31.01.2021.
Actual submission date: 28.01.2021.
Partner responsible: TECSR
Reviewed by: TEC

To the initial version of MEA basis for sensing based on the state-of-the-art sensors and physiological strain modelsIt contains information about the alpha prototype design, dimensions, manufacturing process and proposed positioning. 

The alpha prototype of the MEA basis for sensing is based on the requirements defined in D2.1, focusing on the available technology and existing models for physiological strain.  

The alpha version comprises a two lead ECG sensor and an NTC thermistor for measurement of the skin temperature. From the proposed design, advanced functional prototypes of MEAs will be iteratively developed to allow testing and validation in both laboratory and field conditions. Current design will serve as a test bed for further research and development, that will lead to a high level of integration of novel sensors to the existing architecture later in the project. 

MEA basis prototype with NTC thermistor subsequently added (down).

First step towards fully integrated, single-substrate biosensing system was made by designing and manufacturing MEA basis with two ECG sensors and one NTC thermistor. The presented MEA basis is designed and developed using state of the art technologies and knowledge to be used for Alpha demonstration purposes.  

Technical drawing (left) and positioning of the MEA basis illustrated on 3D human body model (right).

Technical drawing (left) and positioning of the MEA basis illustrated on 3D human body model (right).
 
MEA-positioning
 MEA basis positioning on five different body sites.

Due date: 30.04.2021.
Actual submission date: 30.04.2021.
Partner responsible: GES
Reviewed by: SHG

To design and manufacture a prototype of integrated SIXTHSENSE embedded system which integrates data acquisition and electrical stimulation units. The design must comply with the requirements defined in D2.1, D7.1 and D9.1. 

Based on the existing technology and GES knowhow a wearable health monitoring system with closed loop electrotactile biofeedback that that allows first responders in hazardous situations to sense their current health status was developed. The design was made in compliance with the modular architecture proposed in D9.1 that allows for it to be used in a standalone device, or as an integral module of the SIXTHSENSE wearable hub alpha prototype.

The developed Alpha mobile device is equipped with an ARM Microcontroller, acquisition system, electrotactile stimulation system, communication with command center, battery and interfaces. Set up of the equipment that was used for requirement verification is displayed in the image below.

                   

The manufactured prototype fulfils all required characteristics, based on results of functional tests, as well as hardware photographs presented in this  deliverable.

Due date: 31.10.2021.
Actual submission date: 31.10.2021.
Partner responsible: TECSR
Reviewed by: TEC

The aim of this deliverable is to serve as a supplementary document to the second version of SIXTHSENSE MEA basis for sensing prototypes, providing technical data on: configuration, shape and size of different sensors included, technical drawings, manufacturing process, proposed positioning.

The design of second version of SIXTHSENSE MEA can be seen in the image below. Beta prototype includes the following recording sites: 3 circular ECG electrodes (2 active and 1 reference pad), 4 standard 3-electrode cell configuration for chronoamperometric measurements of lactate, surrounded by two concentric electrodes for iontophoretic extraction, 2 standard 3-electrode cell configuration for open circuit potential (OCP) measurements of Na+ and K+ ions, NTC (Negative Temperature Coefficient) thermistor for temperature measurement.